Enhancing Genome Editing Using Repair Templates

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Closed

FOCUS AREA: Traits

We are interested in developing partnerships with outstanding academic scientists to pursue advancements in template-based CRISPR-Cas genome editing. Homology directed repair (HDR) approaches enable defined sequence changes and insertions by utilizing donor templates to instruct cellular repair of a CRISPR-Cas induced break of genomic DNA. Achieving HDR in plants requires generating and screening hundreds of plants with success rates varying among experiments. To help realize the potential of genome editing we recognize the need to support innovation with monetary grants, access to leading-edge technologies, and knowledgeable collaborators.

This opportunity is now closed.

What we are Seeking

Solutions for enhancing the recovery of template-based CRISPR-Cas editing including:
- Molecular approaches that enhance the underlying efficiency of HDR
- Non-HDR solutions that achieve similar outcomes
- Environmental or tissue-culture conditions
- Design/reagent parameters that drive efficiency
- Informatic approaches predictive of efficiency
- in planta reporter systems that are predictive of efficiency
- Other areas that enhance the efficiency of template based editing
Solutions that apply directly to plants and/or are applicable to plant tissue culture

Open Innovation

What we are Seeking