Current Opportunities

Explore our current grants and collaboration opportunities.
23 Days Left

Insect midgut epithelial cell culture systems

Focus Area: Enabling Technologies

Cell cultures are used in many fields of biological research to look at cellular responses to external inputs. They can serve as a predictor of responses by the whole organisms from which they were derived.  In the field of entomology, several types of cell-based assays have been used successfully to characterize cellular responses1,2.  In many of the described cases, the cell-based assays utilized recombinant techniques within cell lines to recreate the physiological target of an input. Alternatively, cell lines derived from non-midgut tissue that happened to be naturally susceptible to an insecticidal protein were used.

Primary cell cultures tend to closely resemble the morphology and physiological state of the cells they were isolated from3.  Therefore, the response of primary insect cell cultures may better reflect that of the intact insect than reconstituted cell lines without requiring prior knowledge of a response mechanism. However, it is challenging to isolate and culture midgut epithelial cells continuously and to preserve their differentiation capability as, to date, very few proliferation and differentiation factors specific to insect midgut cells have been identified.

At Corteva Agriscience™, our goal is to develop effective, sustainable, and durable solutions to agricultural challenges. We are looking for cell culture systems that combine the ease of use and reproducibility of cell lines with the preserved physiological status of primary cell culture.  We invite public and private sector scientists to join in our efforts by submitting a research proposal to develop insect midgut epithelial cell culture systems.


1 Soberón, M., Portugal, L., Garcia-Gómez, B.I., Sanchez, J., Onofre, J., Gomez, I., Pacheco, S., Bravo, A., 2018. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis. Insect biochemistry and molecular biology 93:66-78.

2 Smagghe, G., Goodman, C.L. and Stanley, D., 2009. Insect cell culture and applications to research and pest management. In Vitro Cellular & Developmental Biology-Animal 45:93-105.

3 Mandrioli, M., Monti, M., and Tedeschi, R., 2015.  A practical guide to insect cell cultures: establishment and maintenance of primary cell cultures. Halteres 6:132-141.

Who Should Apply

Scientists in the public and private sector

Amount Awarded

(up to $50,000 including a maximum of 10% indirect costs)

Submission Date

September 15, 2019

Learn More


Challenges are being managed by InnoCentive.

92 Days Left

Methods for Determining Similar Sequences Across Genomes

Focus Area: Breeding

Individuals of a species differ from one another at the genetic level to various degrees. These differences represent different genotypes, or genetic constitutions, within a species. To better understand the genetic content of each individual genome, it is important to understand similarities and differences of gene sequences and their sub-components when compared across genomes.

At Corteva Agriscience™, we develop robust and sustainable agriculture solutions and drive innovation through technologies including genomics.  We are seeking a methodology to accurately identify similar gene sequences across genomes from individuals of a single species. This is a Reduction-to-Practice Challenge that requires written documentation and output from the data analysis algorithm, and submission of source code and executable if requested.

Corteva Crowdsourcing Challenges are being managed in collaboration with InnoCentive. To learn more and participate in this challenge, you will be leaving the Corteva Open Innovation website.

This opportunity is now closed.

Who Should Apply

Individuals or teams with comparative genomics and/or bioinformatics expertise

Amount Awarded

Up to $50,000

Submission Date

November 23, 2019

Apply at InnoCentive

Past Opportunities


Thank you for your interest in Pioneer Hi-Bred International Inc.’s (“Pioneer’s”) Open Innovation website.  We ask you to read these Terms and Conditions carefully because you must agree to them before applying for a grant or submitting a proposal, an idea for collaboration, or any other information (collectively a “Submission”). 

If Pioneer is interested in pursuing your Submission, we will contact you and may enter into a confidentiality agreement to further discuss the Submission.  If we decide to work together we may enter into a separate agreement.


These Terms and Conditions apply to your use of the Open Innovation website, including any Submissions.  Other terms and conditions pertinent to the use of other Pioneer websites may also apply. 

No Confidential Information

In your Submission, include only enough information for Pioneer’s basic understanding of the subject matter.  Pioneer does not want to receive your confidential or proprietary information or that of any third party through the Open Innovation website.  When making a Submission, you understand that is treated as non-confidential and there are no restrictions on how Pioneer can use the Submission.  By making a Submission, you are free to continue to develop the subject matter of your Submission, apply for or seek other funding, publish, or seek other collaboration opportunities. 


By making a Submission, you warrant that:

  • you own the Submission;
  • your Submission does not violate any third party rights (for example, patent rights, copyrights, trademark rights, trade secret rights, right of privacy, or any other right), including rights of your former or current employers, or any applicable law or regulation;
  • if you are submitting on behalf of your employer, you are an authorized representative of your employer;
  • your Submission does not contain any material or information (including text, links, communications, software, images, sounds, data, or other information) that constitutes advertising or promotion, junk mail, “spamming,” chain letters, or will intentionally interfere with the operation of DuPont and/or DuPont Pioneer websites, computer systems, or electronic devices.


Acknowledgement and Waivers

You acknowledge that Pioneer is not obligated to enter into any agreement with you related to your Submission and it is at Pioneer’s sole discretion as to whether a grant will be issued or whether a collaboration will be carried out related to your Submission.  You acknowledge that Pioneer has active research programs in the subject matter of your Submission and may already be aware of the subject matter contained in your Submission.  You acknowledge and agree that Pioneer and/or its designees may create or have created or may obtain or have obtained other submissions that may be similar to or the same as your Submission.  With respect to your Submission, you hereby waive all claims you may have now or in the future, against Pioneer or its affiliated companies.

Governing Law

This Terms and Conditions, and the relationship established hereunder, shall be interpreted and construed in accordance with the laws of the State of Delaware, United States of America, without regard to its principles of conflicts of laws, and with the same force and effect as if fully executed and performed therein.

10/2017 - Pioneer reserves the right to amend these Terms and Conditions from time to time in its sole discretion.