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Insect midgut epithelial cell culture systems

Focus Area: Enabling Technologies

Cell cultures are used in many fields of biological research to look at cellular responses to external inputs. They can serve as a predictor of responses by the whole organisms from which they were derived.  In the field of entomology, several types of cell-based assays have been used successfully to characterize cellular responses1,2.  In many of the described cases, the cell-based assays utilized recombinant techniques within cell lines to recreate the physiological target of an input. Alternatively, cell lines derived from non-midgut tissue that happened to be naturally susceptible to an insecticidal protein were used.

Primary cell cultures tend to closely resemble the morphology and physiological state of the cells they were isolated from3.  Therefore, the response of primary insect cell cultures may better reflect that of the intact insect than reconstituted cell lines without requiring prior knowledge of a response mechanism. However, it is challenging to isolate and culture midgut epithelial cells continuously and to preserve their differentiation capability as, to date, very few proliferation and differentiation factors specific to insect midgut cells have been identified.

At Corteva Agriscience™, our goal is to develop effective, sustainable, and durable solutions to agricultural challenges. We are looking for cell culture systems that combine the ease of use and reproducibility of cell lines with the preserved physiological status of primary cell culture.  We invite public and private sector scientists to join in our efforts by submitting a research proposal to develop insect midgut epithelial cell culture systems.

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1 Soberón, M., Portugal, L., Garcia-Gómez, B.I., Sanchez, J., Onofre, J., Gomez, I., Pacheco, S., Bravo, A., 2018. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis. Insect biochemistry and molecular biology 93:66-78.

2 Smagghe, G., Goodman, C.L. and Stanley, D., 2009. Insect cell culture and applications to research and pest management. In Vitro Cellular & Developmental Biology-Animal 45:93-105.

3 Mandrioli, M., Monti, M., and Tedeschi, R., 2015.  A practical guide to insect cell cultures: establishment and maintenance of primary cell cultures. Halteres 6:132-141.

Who Should Apply

Scientists in the public and private sector

Amount Awarded

(up to $50,000 including a maximum of 10% indirect costs)

Submission Date

September 15, 2019

Learn More

Challenges

Challenges are being managed by InnoCentive.

92 Days Left
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Methods for Determining Similar Sequences Across Genomes

Focus Area: Breeding

Individuals of a species differ from one another at the genetic level to various degrees. These differences represent different genotypes, or genetic constitutions, within a species. To better understand the genetic content of each individual genome, it is important to understand similarities and differences of gene sequences and their sub-components when compared across genomes.

At Corteva Agriscience™, we develop robust and sustainable agriculture solutions and drive innovation through technologies including genomics.  We are seeking a methodology to accurately identify similar gene sequences across genomes from individuals of a single species. This is a Reduction-to-Practice Challenge that requires written documentation and output from the data analysis algorithm, and submission of source code and executable if requested.

Corteva Crowdsourcing Challenges are being managed in collaboration with InnoCentive. To learn more and participate in this challenge, you will be leaving the Corteva Open Innovation website.

This opportunity is now closed.

Who Should Apply

Individuals or teams with comparative genomics and/or bioinformatics expertise

Amount Awarded

Up to $50,000

Submission Date

November 23, 2019

Apply at InnoCentive

Past Opportunities

 

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